Table 3

Characteristics of children who presented with seizures in association with the use of quinolones

Age	M/F	Medical history	Reason for quinolone use	Quinolone	Dosing and administration	Association with quinolone use	Quinolone discontinued	Outcome
Children with CNS disorders who developed seizures
8 months	M	Pneumonia, herpes stomatitis, hepatitis, diseminated intravascular coagulation	Haemophilus meninigitis	Trovofloxacin	5 mg/kg loading dose, then 2.5 mg/kg 12-hourly IV	Unlikely; seizure developed 11 days after stopping trovafloxacin	No	No long-term morbidity
N/A	N/A	Leukaemia and Cryptococcus neoformans meningitis	Febrile neutropaenia	Gatifloxacin	15 mg/kg 24-hourly PO	N/A	N/A	N/A
Children without CNS disorders who developed seizures
1.25 years	M	Pneumonia	Pneumonia	Ciprofloxacin	10 mg/kg 12-hourly IV	Possible	N/A	No long-term morbidity
3 months 24 days	F	Bronchiolitis	Pneumonia	Ciprofloxacin	10 mg/kg 12-hourly IV	Unlikely	Yes	No long-term morbidity
N/A	N/A	N/A	Pneumonia	Levofloxacin	10 mg/kg 12-hourly (administration details not provided)	Possible; described as a ‘febrile convulsion’	N/A	N/A
2.5 years	N/A	N/A	Shigella flexneri enteritis	Ciprofloxacin	10 mg/kg 12-hourly PO	N/A	N/A	N/A

N/A, data not available; IV, intravenous administration; PO, oral administration.